Top 10 Methylated Multivitamin Supplements 2024

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Taking the best methylated multivitamin can make all the difference when it comes to ensuring optimal health. Methylated vitamins are especially beneficial for those with the MTHFR gene mutation, as they support the body’s methylation process. Let’s dive into the top 10 methylated multivitamin supplements for 2024 that will help you achieve your health goals.

Our Top 3 Picks for Best Methylated Multivitamin Supplements

  • Garden of Life – mykind Organics Women’s Multivitamin: It supports energy production and overall health, making it an excellent choice for women looking for a clean, effective supplement.
  • Jarrow Formulas – B-Right Complex: This formula is designed to enhance the methylation process and support cognitive function, making it a top choice for individuals seeking targeted B vitamin support.
  • Pure Encapsulations – PureGenomics Multivitamin: Designed to support the methylation process and enhance nutrient bioavailability, it is ideal for individuals with the MTHFR gene mutation looking for a high-quality supplement to improve their overall health.

What is the Methylation Process?

Garden of Life – mykind Organics Women’s Multivitamin | Best Methylated Multivitamin Supplements

The methylation process is crucial for numerous bodily functions, including DNA repair, detoxification, and neurotransmitter production. It’s essentially the body’s way of turning certain genes on and off and facilitating biochemical reactions. For those with the MTHFR gene mutation, the body’s ability to methylate properly is compromised. This is why methylated vitamins, which are more bioavailable forms of nutrients, are essential.

Why Are Methylated Multivitamins Important?

Methylated multivitamins provide the active forms of vitamins that your body can easily absorb and utilize. This is particularly important for individuals with the MTHFR gene mutation, who struggle with converting folic acid into its active form. These supplements help bridge the nutritional gap and ensure proper methylation, which is critical for overall health and well-being.

Top 10 Methylated Multivitamin Supplements for 2024

1. Pure Encapsulations – PureGenomics Multivitamin

Pure Encapsulations offers a comprehensive formula with methylated B vitamins, including methylfolate and methylcobalamin. It’s designed to support the methylation process, enhance nutrient bioavailability, and support overall health. This multivitamin also includes other essential vitamins and minerals, making it a well-rounded option for daily supplementation.

2. Thorne Research – Methyl-Guard Plus

Thorne Research is renowned for its high-quality supplements. Methyl-Guard Plus contains active forms of folate (5-MTHF), B12 (methylcobalamin), and B6 (pyridoxal 5′-phosphate), which are essential for the methylation cycle. This formula is particularly beneficial for those with the MTHFR gene mutation, providing enhanced support for cardiovascular, cognitive, and overall health.

3. Seeking Health – Optimal Multivitamin

Formulated by Dr. Ben Lynch, Seeking Health’s Optimal Multivitamin provides a robust blend of methylated vitamins, minerals, and antioxidants. It includes high-potency methylfolate and methylcobalamin, along with other vital nutrients to support detoxification, energy production, and overall wellness. This multivitamin is designed to fill nutritional gaps and support optimal health.

4. Life Extension – Two-Per-Day Multivitamin

Life Extension’s Two-Per-Day formula includes methylated folate (5-MTHF) and B12 (methylcobalamin), ensuring optimal absorption and utilization by the body. This multivitamin also provides a broad spectrum of essential vitamins, minerals, and antioxidants, supporting overall health and longevity.

5. Jarrow Formulas – B-Right

Jarrow Formulas offers a balanced B-complex that includes methylated B vitamins, such as methylfolate and methylcobalamin. This supplement supports energy production, cognitive health, and the methylation process. It’s an excellent option for those who need targeted B vitamin support.

6. Garden of Life – mykind Organics Women’s Once Daily

This organic multivitamin includes methylated B vitamins and caters specifically to women’s health needs, including hormonal balance, energy support, and immune health. Made from whole foods, mykind Organics Women’s Once Daily provides a convenient and clean option for women seeking comprehensive nutritional support.

7. MegaFood – Multi for Men

MegaFood provides a whole food-based multivitamin with methylated nutrients, designed to support men’s unique nutritional needs. This formula includes methylfolate and methylcobalamin, along with other essential vitamins and minerals to promote energy production, immune health, and overall vitality.

8. Solgar – Metafolin Folate

Solgar’s Metafolin Folate is a highly bioavailable form of folate that supports the methylation process and overall health. This supplement is ideal for individuals with increased folate needs or those with the MTHFR gene mutation, providing effective support for cardiovascular and cognitive health.

9. NOW Foods – ADAM Men’s Multivitamin

NOW Foods’ ADAM Multivitamin includes methylated forms of folate and B12, supporting energy levels, immune function, and overall wellness for men. This formula is packed with essential nutrients, antioxidants, and botanical extracts to promote optimal health and vitality.

10. Nature’s Plus – Source of Life Gold

Nature’s Plus offers a comprehensive multivitamin with methylated nutrients, promoting optimal health and vitality. This formula includes whole food concentrates, herbal extracts, and essential vitamins and minerals, providing broad-spectrum nutritional support. It’s designed to enhance energy levels, immune function, and overall well-being.

How to Choose the Best Methylated Multivitamin

Selecting the best methylated multivitamin depends on individual health needs and genetic factors. Here are some tips:

  • Check the Form of Vitamins: Ensure the multivitamin contains methylated forms of B vitamins, especially folate (as L-methylfolate) and B12 (as methylcobalamin).
  • Look for Comprehensive Formulas: Opt for multivitamins that include a range of essential nutrients, not just B vitamins.
  • Consider Your Specific Needs: Women, men, and children have different nutritional requirements. Choose a multivitamin tailored to your demographic.
  • Consult with a Healthcare Professional: Especially if you have the MTHFR gene mutation or other health concerns, seek advice from a healthcare provider.


Why is the MTHFR gene mutation significant?

The MTHFR gene mutation affects the body’s ability to methylate properly, which is crucial for detoxification, DNA repair, and neurotransmitter production. Those with this mutation benefit significantly from methylated vitamins.

Can I get methylated vitamins from food?

While some foods contain naturally methylated vitamins, supplementation ensures you get adequate amounts, especially if you have absorption issues or genetic mutations.

How do I know if I have the MTHFR gene mutation?

Genetic testing through your healthcare provider can determine if you have the MTHFR gene mutation. Symptoms such as fatigue, depression, and high homocysteine levels can also be indicators.


Incorporating a high-quality methylated multivitamin into your daily regimen can significantly improve your health, especially if you have the MTHFR gene mutation. The supplements listed above are some of the best on the market for 2024, ensuring you receive the necessary nutrients in their most bioavailable forms. Always consult with a healthcare professional before starting any new supplement regimen.

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